The Look AHEAD Research Program: A 25-Year Retrospective From the Perspective of Geroscience.
Abstract
The 10-year Action for Health in Diabetes (Look AHEAD) clinical trial compared a multidomain intensive lifestyle intervention to a diabetes support and education program with respect to major cardiovascular disease events (primary outcome) and other diabetes- and obesity-related outcomes. Follow-up of the cohort continues to add other aging-related outcomes and conditions to identify the long-term consequences of factors related to lifestyle and medical care. In this transition to a study of aging among individuals at risk for accelerated aging due to type 2 diabetes and overweight or obesity, the investigators have retrospectively reframed the study using the perspective of geroscience. This perspective strengthens the importance of lifestyle changes as a core component for medical care for these individuals to slow biological aging.
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Research summary
The paper claims that lifestyle changes are essential for slowing biological aging in individuals at risk for accelerated aging due to type 2 diabetes and obesity. This research is relevant as it addresses lifestyle interventions as a means to potentially mitigate the biological processes of aging rather than merely treating age-related diseases.
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