A gut microbiota-stem cell axis mediates the anti-intestinal aging effect of fucoidan from Apostichopus japonicus.

Houyang Sun, Biqian Wei, Yaoguang Chang, Tiantian Zhang, Shaoli Song, Simin He, Qingjuan Tang

State Key Laboratory of Marine Food Processing and Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, China.State Key Laboratory of Marine Food Processing and Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, China. · pubmed

Paper

Abstract

Apostichopus japonicus is a traditional medicinal and culinary species, with existing anti-aging research primarily focusing on its bioactive peptides. In contrast, the anti-aging potential of its major polysaccharide, fucoidan (Aj-FUC), remains largely unexplored. Since the intestine is a central target in the aging process and the primary site for polysaccharide interaction, this study investigates the protective effects and underlying mechanisms of Aj-FUC against d-galactose (d-Gal)-induced intestinal senescence in mice.

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Research summary

The paper claims that fucoidan from Apostichopus japonicus can mitigate intestinal aging through a gut microbiota-stem cell axis. This research addresses a potential mechanism related to the aging process, focusing on the gut's role in longevity.

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