DNA methylation-based surrogate markers of C-reactive protein and their associations with health-related traits.
Abstract
Several methylation-based surrogate markers of C-reactive protein (mCRP) have been proposed and used to assess the risk of age-related phenotypes and construct novel ageing markers. We aimed to (i) assess the variance in plasma CRP explained by several mCRP markers; (ii) compare their associations with three health-related traits: mortality, body mass index (BMI), and PCGrimAge; and (iii) assess the stability of CRP and mCRP over a decade. Blood samples were collected from 947 participants in the Melbourne Collaborative Cohort Study at baseline (1990-1994) and wave 2 (2003-2007). High-sensitivity CRP was measured in plasma samples. Five mCRP markers were calculated: mCRP-Ligthart, mCRP-Wielscher, mCRP-EpiScore, mCRP-GrimAge2, and mCRP-Hillary. Intraclass correlation coefficients (ICCs) were calculated to assess the stability of CRP/mCRP between baseline and wave 2. Associations of wave 2 CRP/mCRP with mortality (N
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Research summary
The paper investigates the associations between DNA methylation-based surrogate markers of C-reactive protein and health-related traits, including mortality. The study is relevant as it explores potential biomarkers that could be linked to aging processes and age-related health outcomes.
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