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RESEARCH PAPER / 2026-01-21

Frailty in Focus - A Scoping Review of Frailty Instruments on from the Kidney Disease Aging Research Collaborative.

Devika Nair, Ilana Mittleman, Juliana Magro, Benjamin Catanese, Mary F Hannan, Melissa D Hladek, Jingyao Hong, Nan-Su Huang, Matthew H Taylor, Karthik K Tennankore, Dawn F Wolfgram, Rasheeda K Hall, Mara McAdams-DeMarco

Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN.Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN. · pubmed

Abstract

Frailty is a multi-system syndrome of decreased physiologic reserve with high prevalence, early incidence, and prognostic significance in kidney disease. Apart from the Physical Frailty Phenotype (PFP), less is known regarding psychometric properties of other instruments. We critically appraise the validity and reliability of frailty instruments across the kidney disease continuum, acknowledge limitations, and highlight knowledge gaps.

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Research summary

The paper critically appraises the validity and reliability of frailty instruments across the kidney disease continuum. The focus on frailty in the context of kidney disease is relevant to aging research as it addresses a significant aspect of physiological decline associated with aging.

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