α -Klotho Promotes Cell Death and Suppresses Inflammation through TNF-Cellular Inhibitor of Apoptosis Protein 1 Signaling in Autosomal Dominant Polycystic Kidney Disease.
Abstract
α Klotho as an antiaging protein can extend the lifespan of healthy animals; serum α Klotho was lower in patients with autosomal dominant polycystic kidney disease. Transgenic α Klotho and recombinant α Klotho delayed cyst growth in Pkd1 mutant mouse kidneys. α Klotho exerted its proapoptotic and anti-inflammatory function through interacting with and destabilizing cellular inhibitor of apoptosis protein 1.
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Research summary
α Klotho promotes cell death and suppresses inflammation through TNF-CIAP1 signaling in autosomal dominant polycystic kidney disease. The study explores the role of α Klotho, an anti-aging protein, in delaying disease progression, which aligns with research focused on the mechanisms of aging and potential interventions.
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