Hypoxia Increases Cardiac Proteasomal Activity and Differentially Modulates Cullin-RING E3 Ligases in the Naked Mole-Rat

W Aline Ingelson-Filpula, Karen L Kadamani, Mohammad Ojaghi, Matthew E Pamenter, Kenneth B Storey

Clark H Smith Brain Tumour Centre, University of Calgary, Calgary, AB T2N 1N4, Canada.Clark H Smith Brain Tumour Centre, University of Calgary, Calgary, AB T2N 1N4, Canada. · pubmed

Paper

Abstract

(1) Background: The naked mole-rat (

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Research summary

Hypoxia increases cardiac proteasomal activity and modulates Cullin-RING E3 ligases in the naked mole-rat. The study investigates cellular mechanisms in a species known for its longevity, potentially shedding light on the biological processes that contribute to aging and lifespan extension.

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