Associations Between Growth Differentiating Factor-15 and Frailty in Older Adults From the MAPT Study.
Abstract
Frailty is a prevalent syndrome in older adults and is associated with increased vulnerability to adverse health outcomes. Growth differentiation factor 15 (GDF-15), a cytokine involved in mitochondrial dysfunction and inflammation, has been proposed as a potential biomarker for age-related conditions. Evidence on the association between GDF-15 and frailty in older adults is limited. This study explores the relationship between plasma GDF-15 levels and frailty onset in community-dwelling older adults.
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Research summary
The paper investigates the association between plasma GDF-15 levels and frailty onset in older adults. This research is relevant as it explores a potential biomarker related to frailty, which is a significant aspect of aging and its associated health outcomes.
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