Aging Reshapes γ/δ T-Cell Immunity Through a Type I Interferon-Foxo1 Axis.

Aurélie Durand, Sarah Porte, Eryang Xing, Christian Wu, Agnès Le Bon, Cédric Auffray, Bruno Lucas, Bruno Martin

Université Paris-Cité, Institut Cochin, Centre National de la Recherche Scientifique (CNRS) UMR8104, Institut National de la Santé et de la Recherche Médicale (INSERM) U1016, Paris, France. · pubmed

Paper

Abstract

Aging is associated with profound alterations in immune cell composition and function, yet the impact on peripheral γ/δ T-cell subsets remains incompletely understood. Here, we show that the peripheral γ/δ T-cell compartment is markedly remodeled with age in mice. Specifically, innate-like Ly-6C

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Research summary

The paper claims that aging remodels the peripheral γ/δ T-cell compartment through a Type I Interferon-Foxo1 axis. This research is relevant as it investigates the immune system's alterations due to aging, which could provide insights into the underlying mechanisms of aging and potential interventions.

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