IGF2BP3-dependent glutamine/BCAA metabolic rewiring rejuvenates aged human adipose-derived stem cells for enhanced tissue regeneration.

Zichao Li, Lin Feng, Xinxin Wei, Huichen Li, Yifu Zhu, Hongtao Wang, Jiaqi Liu, Liang Luo, Zhao Zheng, Baoqiang Song, Liangliang Shen, Dahai Hu

Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. · pubmed

Paper

Abstract

Aging impairs the regenerative capacity and differentiation potential of human adipose-derived stem cells (hASCs), but the mechanisms underlying their functional decline remain unclear. Through systematic functional assays and in vivo experiments, we first confirmed age-associated reductions in hASC self-renewal, lineage plasticity, and tissue repair efficacy. By integrating multiomics profiling and functional validation, we identified a metabolically active ACTA2

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Research summary

The paper claims that IGF2BP3-dependent metabolic rewiring can rejuvenate aged human adipose-derived stem cells for improved tissue regeneration. This research addresses the decline in regenerative capacity associated with aging, focusing on mechanisms that could potentially reverse aspects of aging rather than merely treating age-related symptoms.

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