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RESEARCH PAPER / 2026-01-21

The role of frailty in the association between testosterone levels and mortality risk in older men.

Panpan Zhang, Wenzhen Hao, Wen Ji, Tangbin Yuan, Jing Dai, Li Ji, Weiwei Sheng, Shuying Li

Department of General Practice, Aerospace Center Hospital, Beijing, 100049, China. · pubmed

Abstract

Testosterone plays an important role in male aging, yet its impact on mortality remains unclear. Frailty, a syndrome of physiological decline, may mediate this relationship. This study investigates the mediating role of frailty in the association between testosterone levels and both all-cause and cardiovascular disease mortality in older men.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Frailty mediates the relationship between testosterone levels and mortality risk in older men. This study addresses a potential underlying factor in aging-related mortality, contributing to the understanding of how hormonal changes may influence longevity.

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