Oxymatrine Alleviates Atherosclerosis by Regulating Macrophage Senescence via the SIRT1-P53 Signaling Pathway.

Jun Xiang, Sheng-Quan Wang, Guang-Qiong Zhang, Li-Jin Jiao, Ling-Yun Fu, Yi-Ni Xu, Yu-Ying Wang, Xiang Li, Jun-Lu Tao, Xi-You Yang, Xiao-Shu Cha, Ling Tao, Xiang-Chun Shen

The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, China.The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, China. · pubmed

Paper

Abstract

Recently, macrophage senescence has been identified as an important pathological risk factor for atherosclerosis (AS). Oxymatrine (OMT) has demonstrated potential in ameliorating cellular senescence. This study aims to investigate the pharmacological properties and underlying mechanisms of OMT in alleviating AS progression. High-fat diet-fed ApoE

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Research summary

Oxymatrine alleviates atherosclerosis by regulating macrophage senescence through the SIRT1-P53 signaling pathway. The study addresses macrophage senescence as a pathological factor in atherosclerosis, linking it to aging processes and potential interventions that could impact longevity.

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