Single-Cell Profiling Across Immune Tissues and Organs Reveals Immunosenescence Signatures in Male Rhesus Monkeys.

Shengnan Wang, Zhengna Zhu, Hongju Yang, Yaping Yan, Luyao Ran, Naixue Yang, Yichao Wang, Li Wu, Bing Bai, Weizhi Ji, Wei Si

State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China. · pubmed

Paper

Abstract

Aging gradually impairs immune system function, yet its systemic features across immune organs remain poorly characterized in primates. Here, we perform single-cell transcriptomic profiling of bone marrow, spleen, mesenteric lymph nodes, and peripheral blood mononuclear cells from young and naturally aged male rhesus monkeys. Our study revealed extensive transcriptional remodeling across tissues, particularly the marked upregulation of GZMB expression across multiple cell types in aged monkeys, highlighting it as a candidate biomarker of immunosenescence. Gene regulatory network analysis identifies BHLHE40 as a key transcription factor enriched in multiple CD8

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Research summary

The study identifies GZMB as a candidate biomarker of immunosenescence in aged male rhesus monkeys. This research is relevant as it explores the systemic features of immune aging, contributing to the understanding of the biological mechanisms underlying aging and potential interventions.

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