miR-194-5p-mediated suppression of protein tyrosine phosphatase non-receptor type 12 (PTPN12) expression in the thymus enhances immunologic functional restoration in aged mice.

Ling-Yun Ai, Man-Qin Zhu, Wei-Man Xu, Yong Zou, Hui Huang, Ka Chen, Xia Shuai, Qing-Hua Hu, Zhi-Bin Guo

Postgraduate Affairs Office, Jiangxi Provincial Children's Hospital, Nanchang, 330006, Jiangxi, China. · pubmed

Abstract

This study aimed to explore the role of miR-194 in the post-transcriptional regulation of PTPN12 and its impact on age-related thymic atrophy.

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Research summary

The paper claims that miR-194-5p suppresses PTPN12 expression in the thymus, which enhances immunologic functional restoration in aged mice. This research addresses a mechanism related to age-related thymic atrophy, which is a factor in the aging immune system, thus contributing to the understanding of aging processes.

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