Cellular senescence as a therapeutic target for aging intervention.

Youkun Bi, Guangju Ji

Henan Academy of Sciences, Zhengzhou 450000, China; State Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: [email protected] Academy of Sciences, Zhengzhou 450000, China; State Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: [email protected]. · pubmed

Paper

Abstract

Cellular senescence is a stress-induced cellular state that contributes to tissue dysfunction, chronic inflammation, and a broad range of aging-associated pathologies. The accumulation of senescent cells (SnCs) disrupt normal tissue function, positioning them as drivers of pathological decline and therapeutic targets for aging intervention. Accordingly, multiple senescence-targeted strategies have been developed, including senolytics, senomorphics, senescence immunotherapy, and restoration-oriented interventions. These approaches aim to mitigate senescence-driven pathology by eliminating senescent cells, modulating their secretory activity, or restoring cellular function. Ongoing advancements will require precise stratification of senescent states, careful assessment of long-term safety, and the integration of optimized delivery systems for targeted therapeutic outcomes.

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Research summary

The paper claims that targeting cellular senescence can mitigate aging-related pathologies and improve tissue function. This research is relevant as it addresses the root causes of aging by exploring therapeutic strategies to eliminate or modulate senescent cells, which are implicated in the aging process and associated diseases.

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