Age and sex shape plasma lipid associations to skeletal muscle mitochondrial respiration and H

Nicholas A Carlini, Bradley A Ruple, Helya Rostamkhani, Huihui Shi, J Alan Maschek, Brady E Hanson, Namakkal Soorappan Rajasekaran, Russell S Richardson, Micah J Drummond, Ryan M Broxterman, Joel D Trinity

Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah, USA. · pubmed

Paper

Abstract

Aging changes the lipidome and mitochondrial function in a sex-dependent manner, yet their associations remain poorly understood. Twenty-four younger (7M/17F) and forty-three older (21M/22F) adults underwent blood draws and skeletal muscle biopsies for this cross-sectional investigation. Plasma lipidomic profiling was performed via liquid chromatography-tandem mass spectrometry, while peak mitochondrial O

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Research summary

The paper investigates the associations between plasma lipids and mitochondrial respiration in relation to age and sex. This research is relevant as it explores the underlying biological mechanisms that may contribute to aging and age-related metabolic changes, potentially informing strategies for longevity.

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