Association Between Neutrophil Percentage-Albumin Ratio and Biological Aging in Rheumatoid Arthritis in the United States: A Cross-Sectional Study of NHANES.

Yangyu Xu, Hong Zhao, Yuxiang Gao, Li Zhao, Jiannan Han, Rong Li, Zewen Wu, Junkang Zhao, Liyun Zhang

Rheumatology and Immunology Department, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, Shanxi, China. · pubmed

Paper

Abstract

The accelerating process of global aging has made the burden of age-related diseases increasingly severe, and traditional chronological age fails to reflect individual heterogeneity in aging. The neutrophil percentage-to-albumin ratio (NPAR), is a multidimensional health assessment index composed of inflammatory markers (neutrophils) and nutritional markers (albumin) to reflect inflammation and nutritional status, has shown unique potential in rheumatoid arthritis (RA) research. However, its association with biological age (BA; such as Klemera-Doubal method [KDM] age and phenotypic age, PhenoAge) has not yet been systematically validated in RA patients. By evaluating NPAR indicators in patients with RA, this study intends to reveal its value as a potential biomarker for predicting biological aging and its acceleration.

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Research summary

The study investigates the association between the neutrophil percentage-albumin ratio and biological aging in rheumatoid arthritis patients. This research is relevant as it explores potential biomarkers for biological aging, which could contribute to understanding aging processes and age-related diseases.

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