Integrative proteomics and metabolomics analysis of the mechanism of pancreatic β-cell dysfunction in aged mice.

Fenghui Pan, Long Wang, Xuan He, Can Rong, Yun Hu

Department of Geriatrics, Nanjing Drum Tower Hospital, Nanjing, Jiangsu, China.Department of Geriatrics, Nanjing Drum Tower Hospital, Nanjing, Jiangsu, China. · pubmed

Paper

Abstract

The prevalence of type 2 diabetes mellitus has increased worldwide and is higher among older individuals. Exploring the mechanisms underlying pancreatic β-cell dysfunction may help elucidate the pathogenesis of age-related diabetes.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the mechanisms of pancreatic β-cell dysfunction in aged mice, which may contribute to understanding age-related diabetes. This research addresses a fundamental aspect of aging and its impact on metabolic health, aligning with longevity research goals.

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