Caloric restriction modifies small RNA profiles and engages age-related molecular pathways in the CALERIE trial.

Melissa C Orenduff, Kim M Huffman, Daniel W Belsky, Carl F Pieper, William E Kraus, Virginia B Kraus

Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA. · pubmed

Abstract

Caloric restriction (CR) extends lifespan and enhances healthspan across species. In humans, the CALERIE Phase 2 trial demonstrated that CR improves inflammation, cardiometabolic health, and molecular aging. To explore underlying mechanisms, we examined CR-induced changes vs.

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Research summary

Caloric restriction modifies small RNA profiles and engages age-related molecular pathways. The paper is relevant as it investigates the mechanisms by which caloric restriction may influence aging and healthspan, addressing fundamental aspects of longevity research.

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