Ginsenoside Rb1-enhanced decellularized extracellular matrix hydrogels ameliorates mitochondrial dysfunction and cellular aging in sepsis-induced acute lung injury.

Linlin Gao, Fushuang Zheng, Zhiling Fu, Wei Wang

Department of Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. · pubmed

Paper

Abstract

Sepsis-induced acute lung injury (ALI) is a life-threatening condition with high mortality and limited effective treatments. Aging of alveolar type II (AT2) epithelial cells and mitochondrial dysfunction are key contributors to ALI pathogenesis. Ginsenoside Rb1, a major bioactive component of ginseng, has shown potential in modulating cellular senescence and mitochondrial health. This study aimed to evaluate the therapeutic efficacy of Rb1-loaded lung tissue-derived decellularized extracellular matrix hydrogel (dECM-gel) in alleviating sepsis-induced ALI.

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Research summary

The paper claims that ginsenoside Rb1-loaded decellularized extracellular matrix hydrogels can alleviate mitochondrial dysfunction and cellular aging in sepsis-induced acute lung injury. The study addresses cellular aging and mitochondrial health, which are key factors in the aging process, thus making it relevant to longevity research.

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