Aging-associated GSK3β overexpression exacerbates hepatic ischemia-reperfusion injury through Nrf2 deficiency-induced hepatocyte ferroptosis.

You Wu, Yan Zhang, Shiwei Zhang, Huahong Yang, Xinxin Ci

Institute of Translational Medicine, The First Hospital of Jilin University, Jilin University, Changchun, Jilin, China.Institute of Translational Medicine, The First Hospital of Jilin University, Jilin University, Changchun, Jilin, China. · pubmed

Paper

Abstract

Aging can exacerbate hepatic ischemia-reperfusion injury (HIRI), but the underlying mechanisms remain uncertain. In this study, the mechanisms through which age-related dysregulation of the GSK3β-Nrf2 axis promotes hepatocyte ferroptosis and exacerbates HIRI were investigated.

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Research summary

The paper claims that aging-associated GSK3β overexpression leads to hepatocyte ferroptosis and exacerbates hepatic ischemia-reperfusion injury through Nrf2 deficiency. This research addresses mechanisms related to aging and their impact on age-related diseases, contributing to the understanding of how aging affects liver injury and potential interventions.

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