CNOT3 resists ovarian aging by accelerating oocyte maturation and promoting ESCs differentiation.

Nian Li, Enyuan Huang, Ruiqi Wang, Jiaqi Li, Xiaolong Yuan

National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Laboratory of Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China.National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Laboratory of Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China. · pubmed

Paper

Abstract

Ovarian aging (OA), which is characterized by a decline in the quality and quantity of oocytes, represents a major challenge in reproductive medicine. However, the therapeutic targets and therapeutic methods of OA remain poorly defined. Previous studies have suggested that the embryonic stem cells (ESCs) resist mammalian OA, yet the underlying molecular mechanisms are unclear.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

CNOT3 plays a role in resisting ovarian aging by enhancing oocyte maturation and promoting embryonic stem cell differentiation. This research addresses mechanisms related to ovarian aging, which is a significant aspect of reproductive aging and longevity.

Author of this paper? Send a correction.