The mediating role of insulin resistance in depression driving phenotypic age acceleration.

Li Zhang, QianKun Yang, Jie Yu, Yue Hu

Department of Hematology and Oncology of Children's Hospital of Chongqing Medical University' National Clinical Research Center for Children and Adolescents' Health and Diseases' Ministry of Education Key Laboratory of Child Development and Disorders' Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, No.136 of Zhongshan Second road' YuZhong district', Chongqing, 400014, China.Department of Hematology and Oncology of Children's Hospital of Chongqing Medical University' National Clinical Research Center for Children and Adolescents' Health and Diseases' Ministry of Education Key Laboratory of Child Development and Disorders' Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, No.136 of Zhongshan Second road' YuZhong district', Chongqing, 400014, China. · pubmed

Paper

Abstract

Depression, characterized by significant psychological and physiological alterations, has been proved to tightly associate with insulin resistance (IR) and hallmarks of biological aging. Phenotypic Age Acceleration (PhenoAgeAccel), which quantifies the discrepancy between biological and chronological age, serves as a robust indicator of accelerated aging. However, the interplay between depression, IR, and accelerated aging remains unclear. This study aims to explore the relationship between depression and PhenoAgeAccel, and the potential mediating role of IR in this association.

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Research summary

The paper claims that insulin resistance mediates the relationship between depression and phenotypic age acceleration. This research is relevant as it explores the interplay between psychological factors and biological aging, potentially addressing root causes of aging through the lens of metabolic health.

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