Epigenetic age deceleration reflects exercise-induced cardiorespiratory fitness improvements.

Menno Van Damme, Sanne Stegen, Bram Steenwinckel, Helene Schroé, Gustavo A Reyes Del Paso, Matias M Pulopulos, Rudi De Raedt, Marie-Anne Vanderhasselt, Wim Derave, Femke Ongenae, Jan Boone, Wim Van Criekinge, Ernst R Rietzschel, Tim De Meyer

GRAY - Ghent Research for Aging Young, Ghent University, Watersportlaan 2, 9000, Ghent, Belgium. · pubmed

Paper

Abstract

Epigenetic clocks are emerging as promising biomarkers of biological aging, yet their sensitivity to short-term interventions remains unclear. This pilot study investigates whether the GrimAge clock can capture the effects of a 6-month cycling-based endurance exercise training intervention, with cardiorespiratory fitness (VO

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Research summary

The paper claims that a 6-month cycling-based endurance exercise training can decelerate epigenetic aging as measured by the GrimAge clock. This research is relevant as it explores the potential of exercise to influence biological aging, which is a key aspect of longevity studies.

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