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RESEARCH PAPER / 2026-01-17

Dietary (poly)phenols as modulators of natural killer cell function and immunosenescence: From molecular pathways to clinical evidence.

Asmita Acharya, Giuseppe Mazzola, Mariangela Rondanelli, Patrizia Riso, Simone Perna

Department of Food, Environmental and Nutritional Sciences (DeFENS), Division of Human Nutrition, Università degli Studi di Milano, Milan, Italy. · pubmed

Abstract

Aging is characterized by immunosenescence, involving the decline of Natural Killer (NK) cell function and persistent low-grade inflammation, increasing susceptibility to age-related diseases. Dietary polyphenols have emerged as potential agents to mitigate this decline and enhance immune responses.

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Research summary

Dietary polyphenols can enhance Natural Killer cell function and mitigate immunosenescence. The paper addresses the decline of immune function associated with aging, which is a critical aspect of longevity research.

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