Evaluating the association of apolipoprotein E genotype and cognitive resilience in SuperAgers.

Alaina Durant, Shubhabrata Mukherjee, Michael L Lee, Seo-Eun Choi, Phoebe Scollard, Brandon S Klinedinst, Emily H Trittschuh, Jesse Mez, Lindsay A Farrer, Katherine A Gifford, Carlos Cruchaga, Jason Hassenstab, Adam C Naj, Li-San Wang, Sterling C Johnson, Corinne D Engelman, Walter A Kukull, C Dirk Keene, Andrew J Saykin, Michael L Cuccaro, Brian W Kunkle, Margaret A Pericak-Vance, Eden R Martin, David A Bennett, Lisa L Barnes, Julie A Schneider, William S Bush, Jonathan L Haines, Richard Mayeux, Badri N Vardarajan, Marilyn S Albert, Paul M Thompson, Angela L Jefferson, Paul K Crane, Logan Dumitrescu, Derek B Archer, Timothy J Hohman, Leslie S Gaynor

Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA. · pubmed

Paper

Abstract

"SuperAgers" are oldest-old adults (ages 80+) whose memory performance more closely resembles middle-aged adults. The present study examined apolipoprotein E (APOE) allele frequency in non-Hispanic Black (NHB) and non-Hispanic White (NHW) SuperAgers compared to controls and Alzheimer's disease dementia cases.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that there is an association between apolipoprotein E genotype and cognitive resilience in SuperAgers. This study is relevant as it explores genetic factors that may contribute to cognitive longevity and resilience, which are key aspects of aging research.

Author of this paper? Send a correction.