Childhood adversities and the exposome in dementia risk and brain health.
Abstract
Prevention research has largely concentrated on mid- and late-life modifiable risk factors, whereas early-life adversities have received less attention. Growing evidence shows that early adversities can influence brain health across biological systems and social environments, yet findings are fragmented and rarely address broader structural conditions. This review synthesizes recent evidence and introduces an exposome-informed conceptual model to guide future research and prevention.
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Research summary
Early-life adversities can influence brain health and dementia risk across biological systems and social environments. This paper is relevant as it addresses the long-term effects of early-life factors on brain health, which is crucial for understanding and potentially mitigating age-related diseases.
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