CD38 Inhibition Ameliorates Age-Related CognitiveDecline via a Choroid Plexus-Cerebrospinal Fluid-Hippocampus Axis.

Eric Verdin, Jingqi Fang, Rebeccah Riley, Kevin Schneider, Rosalba Perrone, Prasanna Kumaar, Christina King, Grant Kauwe, Andrea Roberts, Genesis Vega Hormazabal, Yini Zhang, Ethan Millard, Xinran Liu, Wendy Jara, Carlos Galicia Aguirre, Harrison Baker, Natalia Murad, Ben Ambrose, Tommy Tran, Nicolas Martin, Ran Zhang, Durai Sellegounder, Simon Melov, David Furman, Tara Tracy, Akos Gerencser, Birgit Schilling, Lisa Ellerby

Buck Institute for Research on Aging.Buck Institute for Research on Aging. · pubmed

Paper

Abstract

Age-related cognitive decline represents a major and unresolved challenge of human aging. Here, we identify the NAD

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Research summary

Inhibition of CD38 can improve cognitive function in aging through a specific biological pathway involving the choroid plexus and hippocampus. This research addresses mechanisms underlying age-related cognitive decline, which is a significant aspect of aging and longevity.

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