DNA damage in macrophages drives immune autoreactivity via nuclear antigen presentation.

George Niotis, Ermioni S Arvanitaki, Emmanouil Theodorakis, Adrian Schmalen, Thomas Juretschke, Orestis Argyros, Konstantinos C Tsolis, George Bertsias, Elias Drakos, Petra Beli, George A Garinis

Department of Biology, University of Crete, Heraklion, Greece. · pubmed

Paper

Abstract

Aging and DNA damage increase the risk of chronic inflammation and autoimmunity, yet the molecular underpinnings remain unclear. In this study, we uncover a DNA damage-driven mechanism in macrophages that triggers immune autoreactivity. Here, using Er1

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Research summary

DNA damage in macrophages triggers immune autoreactivity, contributing to chronic inflammation and autoimmunity. The study addresses a mechanism related to aging and its impact on immune function, which is pertinent to understanding the root causes of age-related diseases.

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