Chronological lifespan extension and nucleotide salvage inhibition in yeast by isonicotinamide supplementation.

Agata I Kalita, Christopher T Letai, Elisa Enriquez-Hesles, Lindsey N Power, Swarup Mishra, Shekhar Saha, Manikarna Dinda, Dezhen Wang, Pankaj K Singh, Jeffrey S Smith

Department of Biochemistry and Molecular Genetics, Charlottesville, VA; Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Cracow, Poland.Department of Biochemistry and Molecular Genetics, Charlottesville, VA; Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Cracow, Poland. · pubmed

Paper

Abstract

Isonicotinamide (INAM) is an isomer of the NAD

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that isonicotinamide supplementation can extend chronological lifespan in yeast through nucleotide salvage inhibition. This research is relevant as it explores potential mechanisms for lifespan extension, addressing fundamental aspects of aging rather than merely treating age-related diseases.

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