Social Determinants of Health, Biological Aging, and Their Impact on Frailty Risk: Mediation and Interaction Effects Analysis.
Abstract
Social determinants of health (SDoH) are often associated with frailty outcomes, yet the potential role of biological aging (BA) in this relationship remains unclear. This study quantified BA-mediated (PhenoAge, Klemera-Doubal method biological age [KDM-Age]) pathways linking SDoH to frailty and assessed the predictive performance of the biological aging models for risk stratification.
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Research summary
The paper claims that biological aging mediates the relationship between social determinants of health and frailty risk. This research is relevant as it explores the intersection of social factors and biological aging, which could inform strategies for addressing the root causes of aging and frailty.
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