The MetaboHealth Score Enhances Insulin Resistance Metabotyping for Targeted Fat Loss: The PERSON Study.

Jordi Morwani-Mangnani, Fatih A Bogaards, Alexander Umanets, Gabby B Hul, Anouk Gijbels, Gijs H Goossens, Joris Deelen, Marian Beekman, Lydia Afman, Ellen E Blaak, P Eline Slagboom

Section of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands. · pubmed

Paper

Abstract

We previously identified distinct muscle and liver insulin resistance (IR) metabotypes in middle-aged and older adults. The PERSON study showed that a low-fat, high-protein, high-fiber diet benefits the muscle IR group, while a high-monounsaturated fatty acid diet benefits the liver IR group. We also developed the MetaboHealth score, reflecting risks of mortality, frailty, and cognitive decline. This study aimed to examine whether MetaboHealth interacts with IR metabotypes to influence (i) cardiometabolic health and (ii) body composition outcomes in the PERSON study, informing precision nutrition strategies.

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Research summary

The MetaboHealth score interacts with insulin resistance metabotypes to influence cardiometabolic health and body composition outcomes. This paper is relevant as it explores metabolic health factors that could potentially influence aging-related outcomes, such as frailty and cognitive decline, rather than merely addressing symptoms of age-related diseases.

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