Intermittent hypobaric pressure induces selective senescent cell death and alleviates age-related osteoporosis.

Bowen Meng, Yan Qu, Benyi Yang, Chaoran Fu, Yifan He, Jing Li, Rentao Wan, Xin Li, Zhulin Xue, Zeyuan Cao, Meng Hao, Xiao Zhang, Zhe An, Fen Chen, Ruibao Ren, Xueli Mao, Yang Cao, Songtao Shi

Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, South China Center of Craniofacial Stem Cell Research, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China. · pubmed

Paper

Abstract

Senescent cell accumulation contributes to aging, and their clearance represents an effective anti-aging strategy. Current senolytic strategies focus on drug-mediated senescent cell clearance, but it is unknown whether a hypobaric condition can induce senescent cell death. Here we show that hypobaric pressure (HP) at -375 mmHg without hypoxia induces cells to undergo lysosome-dependent cell death (LDCD). Mechanistically, we unveil that HP activates transmembrane protein 59 (TMEM59) to induce cellular Ca

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Research summary

Intermittent hypobaric pressure induces lysosome-dependent cell death in senescent cells. The study addresses the root cause of aging by exploring a novel method for senescent cell clearance, which is a significant aspect of anti-aging strategies.

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