Associations of phenotypic age acceleration, genetic risk, and lifestyle with chronic digestive diseases: A large-scale longitudinal cohort study.

Shuai Xiang, Yixuan Li, Yunlong Li, Shuzhe Xie, Chengfeng Wang, Xu Che, Yongxing Du

Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. · pubmed

Paper

Abstract

Phenotypic age acceleration (PhenoAgeAccel) is a promising biological aging metric, but its associations with chronic digestive disease risk are unclear. This study evaluated these associations and assessed modification by genetic risk and lifestyle.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The study investigates the associations between phenotypic age acceleration, genetic risk, and lifestyle factors with chronic digestive diseases. This paper is relevant as it explores biological aging metrics in relation to disease risk, which can contribute to understanding aging processes and potential interventions.

Author of this paper? Send a correction.