The retinoic acid-related orphan receptors (RORs) signaling axis in skeletal homeostasis: mechanistic insights and chronotherapeutic prospects.

Liangsheng Wei, Qiaoning Yue, Dayong Yang, Shaogang Miao, Mingyao Lu, Zidan Zhang, Xiaoyan Liang, Xiguang Zhang, Yi Zhang

Kunming Medical University, Kunming, China. · pubmed

Paper

Abstract

The global rise in aging populations has substantially increased the clinical and socioeconomic burden of osteoporosis (OP), a disorder characterized by impaired bone formation and excessive resorption. Disruption of circadian rhythmicity is increasingly recognized as a significant contributor to skeletal fragility and fracture risk. The retinoic acid-related orphan receptor (ROR) family-RORα, RORβ, and RORγ-integrates circadian regulation with immune and metabolic pathways essential to bone remodeling, presenting emerging therapeutic opportunities.

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Research summary

The paper explores the role of RORs in skeletal homeostasis and their potential therapeutic implications for osteoporosis. The research addresses the intersection of circadian rhythms and bone health, which are critical factors in aging and longevity.

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