TNFα is a trigger of aging-associated liver inflammation in mice.

Haktan Övül Bozkir, Annette Brandt, Katja Csarmann, Anja Baumann, Katharina Burger, Timur Yergaliyev, Tim Hendrikx, Amélia Camarinha-Silva, Ina Bergheim

Department of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria. · pubmed

Paper

Abstract

Tumor necrosis factor α (TNFα) regulates inflammation in metabolic diseases and probably aging-associated inflammation. Here, TNFα´s role in aging-related liver inflammation and fibrosis and underlying mechanisms was assessed in mice. In male C57BL/6J mice, aging increased hepatic inflammation, senescence markers p16 and p21 and Tnfa mRNA expression in liver tissue. In a second study, 4 and 24-month-old TNFα

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Research summary

The paper claims that TNFα triggers aging-associated liver inflammation and fibrosis in mice. This research is relevant as it investigates the role of TNFα in the mechanisms of aging-related inflammation, which could contribute to understanding the root causes of aging and age-related diseases.

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