Targeted Supramolecular Senolytics by Enzyme-Responsive Disassembly and Intracellular Polymerization.

Sangpil Kim, Jaeeun Lee, Yumi Cho, Hyun-Seo Park, Seung Hak Oh, Jiye Kim, Dohyun Kim, Youjung Sim, Min-Seok Seu, Chaekyu Kim, Sang Kyu Kwak, Ja-Hyoung Ryu

Department of Chemistry, UNIST, Ulsan 44919 (Republic of Korea).Department of Chemistry, UNIST, Ulsan 44919 (Republic of Korea). · pubmed

Paper

Abstract

Recent evidence indicates that elimination of senescent cells from tissue can be a therapeutic approach to treat age-related disease, but selective targeting of senescent cells remains a challenge. Here, we report a dual-responsive self-assembly system selectively targeting senescent cells by responding to two hallmark features: elevated reactive oxygen species levels and increased alkaline phosphatase (ALP) activity. The engineered monomer (

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Research summary

The paper claims to develop a dual-responsive self-assembly system that selectively targets and eliminates senescent cells. This research is relevant as it addresses a potential therapeutic approach to eliminate senescent cells, which are implicated in the aging process and age-related diseases, thus targeting a root cause of aging rather than merely treating symptoms.

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