SOD1 deficiency drives ferroptosis-linked oxidative and reproductive aging, mitigated by ginseng root extract.
Abstract
Aging is accompanied by cumulative oxidative stress that promotes tissue degeneration and reproductive decline. Here, we show that deficiency of superoxide dismutase 1 (SOD1) accelerates oxidative injury and reproductive aging through a ferroptosis-linked redox imbalance, and that ginseng root extract (GR) confers protection across species. Aged hairless Sod1⁻
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Research summary
SOD1 deficiency accelerates oxidative injury and reproductive aging, which can be mitigated by ginseng root extract. The study addresses the underlying mechanisms of oxidative stress and ferroptosis in aging, contributing to the understanding of longevity and potential interventions.
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