The Increased Secretion of Lactate Observed in Obesity and Aging Leads to the Generation of Pathogenic B Cells.

Maria Romero, Amanda Virtue, Kate Miller, Andrew Gelsomini, Dhananjay Suresh, Sophie LaPointe, Suresh Pallikkuth, Daniela Frasca

Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA.Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA. · pubmed

Paper

Abstract

Lactate is a metabolite with immunoregulatory functions. We evaluated lactate secretion and its effects on B cells from individuals with different body composition: Y

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Research summary

The paper claims that increased lactate secretion in obesity and aging contributes to the generation of pathogenic B cells. This research is relevant as it explores a potential mechanism linking metabolic changes in aging and obesity to immune dysfunction, which could inform strategies for addressing age-related diseases.

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