NMNAT1 Activates Autophagy to Delay D-Galactose-Induced Aging in Cochlear Hair Cells.

Yongjie Wei, Wenqing Yang, Han Wu, Mengdie Kong, Dachuan Fan, Yuhua Zhang, Nan Cheng, Jiawei Du, Lingna Guo, Yuyang Li, Ye Zhang, Qian Dai, Wei Cao, Jianming Yang, Qiaojun Fang

Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China. · pubmed

Paper

Abstract

With an aging population, the incidence of age-related hearing loss (ARHL) continues to increase. Aging cells exhibit reduced nicotinamide adenine dinucleotide (NAD

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Research summary

The paper claims that NMNAT1 activation can delay aging effects in cochlear hair cells induced by D-Galactose. This research addresses a mechanism related to cellular aging and its impact on age-related hearing loss, which is a significant aspect of longevity research.

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