Associations of Lifetime Cumulative Estrogen Exposure with Lifecourse Social Exposures, Cognitive Decline, and Dementia Risk Among Postmenopausal White, Black, and Latina Women.

Justina F Avila-Rieger, Benjamin Huber, Sarah E Tom, Whitney R Robinson, Tanisha G Hill-Jarrett, Mateo P Farina, Timothy J Hohman, Nicole Schupf, Adam M Brickman, Richard P Mayeux, Jennifer J Manly

Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, United States.Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, United States. · pubmed

Paper

Abstract

Greater lifetime exposure to estrogen may protect women from cognitive decline and dementia later in life. Gender-related social factors also influence women's cognitive outcomes; however, little is known about how these biological and social influences work together. We examined the extent to which cumulative estrogen exposure and lifecourse social exposures jointly influence late-life memory trajectories and dementia risk among a community-based sample of White, Black, and Latina women.

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Research summary

Greater lifetime exposure to estrogen may protect women from cognitive decline and dementia later in life. The paper explores the interplay between biological factors (estrogen exposure) and social factors on cognitive health, which is pertinent to understanding aging and its associated diseases.

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