Metabolomic sweet spot clock predicts mortality and age-related diseases in the Canadian Longitudinal Study on Aging.
Abstract
Chronological age does not capture individual health or resilience. Advances in metabolomics have enabled development of molecular aging biomarkers that capture deviations between biological and chronological age, highlighting how genetics, environment, and lifestyle shape biological aging. Despite their promise, metabolomic biomarkers face challenges such as interpretability, non-linearity, and reproducibility.
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Research summary
The paper claims that a metabolomic sweet spot clock can predict mortality and age-related diseases. This research is relevant as it explores molecular aging biomarkers that may help in understanding and potentially mitigating the root causes of aging.
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