Integrative computational simulations and functional assays decode allosteric dysregulation in a pathogenic SIRT6 variant.

Haiyue Tang, Jianyang Ao, Guoyou Zhang, Jiacheng Wei, Zongtao Chai, Shaoyong Lu

Shanghai Key Laboratory of Flexible Medical Robotics, Institute of Medical Robotics, Artificial Intelligence Clinical Research Center for Drug Discovery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China; School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China; Department of Pharmaceutical and Artificial-Intelligence Sciences, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, China. · pubmed

Paper

Abstract

SIRT6, a critical member of the NAD

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Research summary

The paper decodes allosteric dysregulation in a pathogenic SIRT6 variant, which is implicated in aging processes. SIRT6 is known to play a role in DNA repair and metabolic regulation, making its study relevant to understanding the mechanisms of aging and potential interventions.

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