α-Klotho Supplementation Mitigates Cumulative Exercise-Induced Fatigue via Coordinated NRF2-Mediated Antioxidant Defense and AKT/GS-Driven Hepatic Glycogen Supercompensation in Mice.
Abstract
Exercise-induced fatigue involves oxidative stress and metabolic dysregulation. While the anti-aging protein α-Klotho regulates metabolism and oxidative stress, its role in exercise fatigue is unexplored. This study investigated whether α-Klotho supplementation mitigates cumulative exercise-induced fatigue and elucidated the underlying tissue-specific mechanisms. Male C57BL/6J mice were divided into three groups (
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Research summary
The paper claims that α-Klotho supplementation can reduce exercise-induced fatigue through specific metabolic pathways. This research is relevant as it explores the role of α-Klotho, an anti-aging protein, in mitigating fatigue, which may relate to broader mechanisms of aging and metabolic health.
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