Hepatic FGF21 Deletion Improves Glucose Metabolism, Alters Lipogenic and

Daniel Torres-Oteros, Mariano Nicola-Llorente, Héctor Sanz-Lamora, Albert Pérez-Martí, Pedro F Marrero, Silvia Canudas, Diego Haro, Joana Relat

Department of Nutrition, Food Sciences and Gastronomy, School of Pharmacy and Food Sciences, Food Torribera Campus, University of Barcelona, 08921 Santa Coloma de Gramenet, Spain.Department of Nutrition, Food Sciences and Gastronomy, School of Pharmacy and Food Sciences, Food Torribera Campus, University of Barcelona, 08921 Santa Coloma de Gramenet, Spain. · pubmed

Paper

Abstract

Fibroblast growth factor 21 (FGF21) is a key hormone for metabolic homeostasis under conditions such as obesity, aging and diabetes. While extensively studied in males, its role in female physiology remains poorly defined. This study evaluated the effects of hepatic FGF21 deletion in 12-month-old female mice using a liver-specific FGF21 knockout (FKO) model. FKO females exhibited reduced body weight and improved glucose tolerance, with no changes in circulating FGF21 levels. In the liver, RT-qPCR analysis showed that the expression of genes involved in de novo lipogenesis, including

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Research summary

Hepatic FGF21 deletion improves glucose metabolism and alters lipogenic gene expression in female mice. This study explores the role of FGF21 in metabolic homeostasis, which is pertinent to understanding mechanisms that could influence aging and age-related metabolic disorders.

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