The testobolome in microbial testosterone metabolism and human health.
Abstract
We propose the term testobolome, analogous to the estrobolome, to describe gut bacteria that metabolize testosterone. Testosterone undergoes microbial transformations similar to estrogens, potentially influencing host hormone homeostasis and health. This review defines the testobolome, identifies its known members, and explores mechanisms that are shared or distinct from the estrobolome. We outline a framework for future research into microbiome-mediated steroid metabolism, including its role in aging and hormone-driven diseases.
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Research summary
The paper proposes the concept of the testobolome, highlighting the role of gut bacteria in metabolizing testosterone and its potential implications for hormone homeostasis and health. This research is relevant as it explores microbial interactions that could influence aging and hormone-driven diseases, addressing aspects of hormone regulation that may contribute to longevity.
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