Betulinic acid abates age-related kidney structural changes and proteinuria by contending oxidative stress in male rats.

C V Haritha, Sunita Kumawat, Pravin Maruti Madabhavi, Meemansha Sharma, Anshuk Sharma, V A Aneesha, Karikalan Mathesh, Sunil E Jadhav, Subhashree Parida, Thakur Uttam Singh, Madhu Cholenahalli Lingaraju

Division of Pharmacology and Toxicology, ICAR-Indian Veterinary Research Institute, Izatnagar, 243 122, India.Division of Pharmacology and Toxicology, ICAR-Indian Veterinary Research Institute, Izatnagar, 243 122, India. · pubmed

Paper

Abstract

Betulinic acid (BA) has shown potent anti-oxidant activity and ameliorated kidney injury in rodent models in our previous studies. Therefore, we were keen to address the prospects of BA in age-related renal changes which are still far from clear.

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Research summary

Betulinic acid reduces age-related kidney structural changes and proteinuria by combating oxidative stress. The study addresses oxidative stress, a key factor in the aging process, and its impact on kidney health, which is relevant to understanding and potentially mitigating age-related diseases.

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