Sex and stimulus-specific differences in endothelial cell senescence under hormone-free conditions.

Anna Quarder, Khaoula Talbi, Hannah Bartmann, Esther Beuke, Constantin von Kaisenberg, Manuel M Vicente, Sara Todorovic, Anette Melk

Department of Pediatric Kidney, Liver, Metabolic and Neurological Diseases, Hannover Medical School, Hannover, Germany.Department of Pediatric Kidney, Liver, Metabolic and Neurological Diseases, Hannover Medical School, Hannover, Germany. · pubmed

Paper

Abstract

Sex differences in cardiovascular disease are well documented, with females often considered hormonally protected. However, some differences persist even after menopause, indicating nonhormonal influences. Endothelial dysfunction is an early contributor to cardiovascular disease, with endothelial cell senescence playing a key role. Senescence, an irreversible cell cycle arrest, can be replicative or stress-induced. This study investigates whether sex differences in endothelial senescence exist independent of hormonal influence and vary by stimulus. Senescence was induced by replication or irradiation in female and male human umbilical vein endothelial cells (HUVECs) (up to

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Research summary

The paper claims that sex differences in endothelial cell senescence exist independent of hormonal influence and vary by stimulus. This research is relevant as it explores mechanisms of endothelial dysfunction, which is a key factor in cardiovascular aging and may contribute to understanding the biological processes underlying longevity and age-related diseases.

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