Caloric restriction attenuates oxidative and inflammatory markers of aging, while compromising germinative epithelium homeostasis in the rat aged testis.

Sabrina Bossio, Daniele La Russa, Gemma Antonucci, Danilo Lofaro, Lidia Urlandini, Maurizio Mandalà, Francesco Conforti, Michele Di Dio, Antonio Aversa, Vittoria Rago, Silvia Di Agostino, Anna Perri

Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, 88100, Italy. · pubmed

Paper

Abstract

Aging is accompanied by a chronic low-grade systemic inflammatory state known as "inflammaging", driven by the accumulation of pro-inflammatory and immunosenescent cells, oxidative stress, and dysregulation of apoptosis and autophagy. Experimental evidence suggests that caloric restriction (CR) can slow down inflammaging, although its impact on spermatogenesis remains controversial. This study aimed to investigate the effects of CR on age-related testicular inflammation and any effects on germ cells.

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Research summary

Caloric restriction reduces oxidative and inflammatory markers of aging in the testis but may negatively affect germ cell homeostasis. This study addresses the impact of caloric restriction on aging-related inflammation, which is a key factor in understanding the mechanisms of aging and potential interventions for longevity.

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