Lack of receptor for advanced glycation end products attenuates obesity-induced adipose tissue senescence in mice.

Zuoqin Du, Jiaqi Wu, Tao Zhang, Xiaoyu Ma, Ziyu Li, Jin Xu, Jingcan You, Ni Chen, Jianbo Wu

Department of Pharmacy, The Second People's Hospital of Yibin, Yibin, China.Department of Pharmacy, The Second People's Hospital of Yibin, Yibin, China. · pubmed

Paper

Abstract

The receptor for advanced glycation end products (RAGE) and its ligands are critical drivers of adipose tissue inflammation. While RAGE expression increases in ageing cells and pathological conditions, its specific role in high-fat diet (HFD)-induced adipose tissue senescence remains to be fully elucidated. In this study, we investigated the function of RAGE in the development of adipose tissue senescence associated with obesity. We observed that HFD-fed RAGE-deficient (RAGE

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Research summary

The paper claims that the absence of RAGE attenuates obesity-induced adipose tissue senescence in mice. This research is relevant as it explores the mechanisms underlying adipose tissue senescence, which is a contributor to aging and age-related metabolic dysfunctions.

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