Combating Blue Light Pollution With Flavonoids: Implications for Environmental Health and Aging.

Abstract

Short-wavelength blue light is commonly encountered in daily life and has been shown to be harmful to the health of organisms. This study aimed to examine the impact of blue light on aging and to explore the potential anti-aging effects of three flavonoids-luteolin, quercetin, and kaempferol-under conditions of blue light exposure. The experiment employed Drosophila melanogaster as a model organism, by feedingvarious concentrations of the three flavonoids and subsequent exposure to short-wavelength blue light. Administration of the highest concentration of the three flavonoids to D. melanogaster was associated with a reduced risk of mortality during adulthood. Male D. melanogaster receiving the highest concentration of flavonoids, as well as those receiving luteolin and quercetin individually, exhibited a reduced initial aging rate (b₀), resulting in an extended mean lifespan and a narrower lifespan distribution compared with the control group. In conclusion, this study demonstrated the effects of flavonoids on the aging process in organisms subjected to blue light. These findings provide important insights into the development of strategies to mitigate aging in the presence of blue-light-induced damage and contribute to a broader understanding of environmental influences on health and aging.